A comparison of commercial microwave reactors for scale-up within process chemistry

JD Moseley, P Lenden, M Lockwood…

Index: Moseley, Jonathan D.; Lenden, Philip; Lockwood, Mark; Ruda, Katinka; Sherlock, Jon-Paul; Thomson, Anthony D.; Gilday, John P. Organic Process Research and Development, 2008 , vol. 12, # 1 p. 30 - 40

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Citation Number: 85

Abstract

Seven commercially available microwave reactors designed for limited scale-up have been investigated using a highly reliable and robust reaction (the Newman− Kwart rearrangement). The use of a single reaction has enabled the comparison to be made across the range of different reactor types and scales. Overall, all reactors gave reliable scale-up from small scale, and performance equivalent to one another on large scale. A ...