Angewandte Chemie. International edition in English 2014-03-10

Highly chemo-, regio-, and enantioselective rhodium-catalyzed cross-cyclotrimerization of two different alkynes with alkenes.

Jun Hara, Mana Ishida, Masayuki Kobayashi, Keiichi Noguchi, Ken Tanaka

Index: Angew. Chem. Int. Ed. Engl. 53(11) , 2956-9, (2014)

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Abstract

It has been established that a cationic rhodium(I)/(R)-tol-binap complex catalyzes the cross-cyclotrimerization of silylacetylenes, di-tert-butyl acetylenedicarboxylates, and acrylamides with excellent chemo-, regio-, and enantioselectivities. Unsymmetrical alkynoates can also be employed in place of di-tert-butyl acetylenedicarboxylate for this process, but with reduced chemoselectivity. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.