Chemical & Pharmaceutical Bulletin 2007-11-01

Cytotoxic metabolites from the wood-decayed fungus Xylaria sp. BCC 9653.

Wipapan Pongcharoen, Vatcharin Rukachaisirikul, Masahiko Isaka, Kanlayanee Sriklung

Index: Chem. Pharm. Bull. 55(11) , 1647-8, (2007)

Full Text: HTML

Abstract

Chemical investigation of the wood-decayed fungus Xylaria sp. BCC 9653 has led to the isolation of a new methyl aminobenzoate (1) together with eleven known compounds. The structures were established by analysis of spectroscopic data. Cytochalasin D (2), one of the known metabolites, exhibited potent cytotoxicity against African green monkey kidney fibroblast (Vero) cells with an IC(50) value of 0.19 microM.