Bioorganic & Medicinal Chemistry Letters 2007-06-01

Novel aminoethylbiphenyls as 5-HT7 receptor ligands.

Magalie Paillet-Loilier, Frédéric Fabis, Alban Lepailleur, Ronan Bureau, Sabrina Butt-Gueulle, François Dauphin, Aurélien Lesnard, Catherine Delarue, Hubert Vaudry, Sylvain Rault

Index: Bioorg. Med. Chem. Lett. 17(11) , 3018-22, (2007)

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Abstract

The synthesis of a series of aminoethylbiphenyls as novel 5-HT(7) receptor ligands is described. The novel derivatives exhibit high affinity for the 5-HT(7) receptor with selectivity toward 5-HT(1A) receptor.