Bioorganic & Medicinal Chemistry 2005-07-15

Synthesis and structure-activity relationships of 2-alkylidenethiazolidine-4,5-diones as antibiotic agents.

Uwe Albrecht, Dirk Gördes, Enrico Schmidt, Kerstin Thurow, Michael Lalk, Peter Langer

Index: Bioorg. Med. Chem. 13(14) , 4402-7, (2005)

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Abstract

2-Alkylidenethiazolidine-4,5-diones were prepared by novel one-pot cyclizations of arylacetonitriles with isothiocyanates and ethyl 2-chloro-2-oxoacetate. The products show antibiotic activity against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus.