Design and synthesis of C-ring lactone-and lactam-based podophyllotoxin analogues as anticancer agents

…, U Faridi, S Srivastava, JK Kumar, MP Darokar…

Index: Singh, Pragya; Faridi, Uzma; Srivastava, Suchita; Kumar, Jonnala Kotesh; Darokar, Mahender Pandurang; Luqman, Suaib; Shanker, Karuna; Chanotiya, Chandan Singh; Gupta, Atul; Gupta, Madan Mohan; Negi, Arvind Singh Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 2 p. 242 - 246

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Citation Number: 12

Abstract

A series of novel podophyllotoxin (PDT) analogues was synthesized in which the lactone moiety was shifted to C ring. Some of the derivatives were also synthesized with modified A ring. Analogues 23 and 25 exhibited potent in vitro cytotoxicity against colon cancer (CaCO 2) cell line. p-Demethylated E-ring analogues exhibited better potency than the corresponding methylated analogues. These analogues showed toxicity comparable to ...