Journal of the American Chemical Society 2008-07-09

Iridium-catalyzed enantioselective hydrogenation of alpha,beta-unsaturated carboxylic acids.

Shen Li, Shou-Fei Zhu, Can-Ming Zhang, Song Song, Qi-Lin Zhou

Index: J. Am. Chem. Soc. 130(27) , 8584-8585, (2008)

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Abstract

A highly efficient iridium-catalyzed hydrogenation of alpha,beta-unsaturated carboxylic acids has been developed by using chiral spiro-phosphino-oxazoline ligands, affording alpha-substituted chiral carboxylic acids in exceptionally high enantioselectivities and reactivities.