Bioorganic & Medicinal Chemistry 2008-03-01

Synthesis and structure-immunosuppressive activity relationships of bakuchiol and its derivatives.

Hongli Chen, Xiaolong Du, Wei Tang, Yu Zhou, Jianping Zuo, Huijin Feng, Yuanchao Li

Index: Bioorg. Med. Chem. 16(5) , 2403-11, (2008)

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Abstract

A series of derivatives of bakuchiol were synthesized and tested in vitro for their cytotoxicity, and inhibition of T cell proliferation and B cell proliferation. The data obtained provided preliminary structure-activity relationships of the compounds as immunosuppressive activity.