«Push??Pull»??Acetylene als Hilfsmittel zur Synthese von Peptiden

M Neuenschwander, HP Fahrni…

Index: Neuenschwander,M. et al. Helvetica Chimica Acta, 1978 , vol. 61, p. 2437 - 2451

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Citation Number: 12

Abstract

Summary 'Push-pull'-acetylenes 1 are excellent reagents for peptide synthesis: Addition of 'push-pull'-acetylenes to solutions of N-protected amino acids (or vice versa) gives enol esters 5, which react selectively with the amino function of a second amino acid. In this way serine, tyrosine, 4-hydroxyproline, cysteine as well as histidine are linked to form dipeptide esters without protection of the second functional group (OH, SH or NH). The amount of ...