Journal of Pharmaceutical and Biomedical Analysis 2012-01-01

Development and validation of reversed phase high performance liquid chromatographic method for determination of moxonidine in the presence of its impurities

Svetlana Milovanović, Biljana Otašević, Mira Zečević, Ljiljana Živanović, Ana Protić, Svetlana Milovanović, Biljana Otašević, Mira Zečević, Ljiljana Živanović, Ana Protić

Index: J. Pharm. Biomed. Anal. 59 , 151-6, (2012)

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Abstract

Highlights ► Moxonidine is a second-generation centrally acting antihypertensive drug. ► An isocratic RP–HPLC method was developed for the analysis of moxonidine and its impurities. ► Central composite design and response surface methodology were used as statistical tools. ► Statistical tools were applied in method development and robustness testing.