Tetrahedron

Carboxamidation of carboxylic acids with 1-tert-butoxy-2-tert-butoxycarbonyl-1, 2-dihydroisoquinoline (BBDI) without bases

Y Saito, H Ouchi, H Takahata

Index: Saito, Yukako; Ouchi, Hidekazu; Takahata, Hiroki Tetrahedron, 2008 , vol. 64, # 49 p. 11129 - 11135

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Citation Number: 29

Abstract

Formation of carboxamides of a variety of carboxylic acids with the coupling reagent BBDI is described. This procedure permits a one pot and simple operation without the need of any bases and no base was required for even use of amine hydrochlorides. In addition, an approach to BBDI-catalyzed carboxamidation is examined.