Synthetic Communications

Aldonitrones as Aldehyde Equivalents: An Efficient, Green, and Novel Protocol for the Synthesis of 1, 8-Dioxo-octahydroxanthenes

D Kumar, Suresh, JS Sandhu

Index: Kumar, Dhruva; Suresh; Sandhu, Jagir S. Synthetic Communications, 2013 , vol. 43, # 20 p. 2739 - 2747

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Abstract

A novel, self-catalyzed, solvent-free, microwave-enhanced, green, and efficient protocol for the synthesis of 1,8-dioxo-octahydroxanthenes and bis-5,5-dimethyl-1,3-cyclohexanediones by condensing aldo-nitrones (imine oxide) and dimedone (5,5-dimethyl-1,3-cyclohexanedione) under microwave irradiation is disclosed. Product formation (viz. xanthenes and bis-5,5-dimethyl-1,3-cyclohexanediones ) is dependent on reaction conditions. The entire process is green and sustainable in ...