Chemical Communications 2014-06-21

tert-Butyl peroxybenzoate (TBPB)-mediated 2-isocyanobiaryl insertion with 1,4-dioxane: efficient synthesis of 6-alkyl phenanthridines via C(sp3)-H/C(sp2)-H bond functionalization.

Jia-Jia Cao, Tong-Hao Zhu, Shun-Yi Wang, Zheng-Yang Gu, Xiang Wang, Shun-Jun Ji

Index: Chem. Commun. (Camb.) 50(49) , 6439-42, (2014)

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Abstract

An efficient method for the construction of 6-alkyl phenanthridines by tert-butyl peroxybenzoate (TBPB)-mediated 2-isocyanobiaryl insertion with 1,4-dioxane was established. Two new C-C bonds were formed in this reaction via a sequential C(sp(3))-H/C(sp(2))-H bond functionalization under metal-free conditions.