Synthesis

α-Isocyanatoacrylonitriles from alkylidene-or arylidenecyanoacetic acids; synthesis and reactions

I Jaafar, G Francis, R Danion-Bougot, D Danion

Index: Jaafar; Francis; Danion-Bougot; Danion Synthesis, 1994 , # 1 p. 56 - 60

Full Text: HTML

Citation Number: 10

Abstract

Alkylidene-or arylidenecyanoacetic acids are versatile synthetic intermediates, readily obtained by Knoevenagel condensation." 2 In this paper, we describe a further application of these compounds. By Curtius reaction, they aﬂord a stereospeciﬁc access to ot- isocyanatoacrylonitriles. We report here some aspects of the usefulness of this functional group interconversion. Curtius reaction has been extensively used for amino acid ...

~49%

~90%

~62%

~76%

Highly Efficient Catalytic Synthesis of α??Amino Acids under...

[Belokon, Yuri N.; Kochetkov, Konstantin A.; Churkina, Tatiana D.; Ikonnikov, Nikolai S.; Larionov, Oleg V.; Harutyunyan, Syuzanna R.; Vyskocil, Stepan; North, Michael; Kagan, Henri B. Angewandte Chemie - International Edition, 2001 , vol. 40, # 10 p. 1948 - 1951]

Method for the racemization of optically active amino acids

[Yamada, Shigeki; Hongo, Chikara; Yoshioka, Ryuzo; Chibata, Ichiro Journal of Organic Chemistry, 1983 , vol. 48, # 6 p. 843 - 846]

Microwave-assisted synthesis of unnatural amino acids

[Young, Douglas D.; Torres-Kolbus, Jessica; Deiters, Alexander Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5478 - 5480]

New synthesis of DL-α-aminoacids from t-butyl N (diphenylmet...

[Bazureau, J.P.; Person, D.; Corre, M. Le Tetrahedron Letters, 1989 , vol. 30, # 23 p. 3065 - 3068]

Hapalocyclamide: a novel phytotoxic hexapeptide of the cyano...

[Tetrahedron Letters, , vol. 53, # 8 p. 977 - 979]