Bioorganic & Medicinal Chemistry Letters 2006-03-15

Synthesis and evaluation of an N-acylated photoactivatable analogue of glutathione as probe for glutathione-utilizing enzymes.

Dan Bernardi, Eric Battaglia, Gilbert Kirsch

Index: Bioorg. Med. Chem. Lett. 16 , 1601-1604, (2006)

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Abstract

The first synthesis of an N-acylated photoactivatable analogue of reduced glutathione is described. N-(4-Benzoylbenzoyl)glutathione (8) was found to be an inhibitor and a photoaffinity probe of purified rat liver glutathione S-transferases.