Soluble Lanthanide Salts (LnCl3⋅ 2 LiCl) for the Improved Addition of Organomagnesium Reagents to Carbonyl Compounds

A Krasovskiy, F Kopp, P Knochel

Index: Krasovskiy, Arkady; Kopp, Felix; Knochel, Paul Angewandte Chemie - International Edition, 2006 , vol. 45, # 3 p. 497 - 500

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Citation Number: 172

Abstract

Lanthanide (iii) salts have been used extensively to activate carbonyl compounds and imine derivatives for the 1, 2-addition of organometallic reagents.[1] Owing to the oxophilic nature of lanthanide salts, the 1, 2-addition reaction is favored over competitive reactions such as enolization and reduction (by β-hydride transfer).[2] The activity of the catalyst strongly depends on the drying procedure [3] and especially on its solubility.[4] Only few ...