FEBS Letters 1988-04-25

Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin.

Y Itoh, M Yanagisawa, S Ohkubo, C Kimura, T Kosaka, A Inoue, N Ishida, Y Mitsui, H Onda, M Fujino

Index: FEBS Lett. 231 , 440, (1988)

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Abstract

A cDNA encoding a human endothelium-derived vasoconstrictor peptide, endothelin, was isolated from a human placenta cDNA library. The nucleotide sequence of this cDNA clone showed that the primary structure of the human preproendothelin has 212 amino acid residues and is highly homologous to porcine preproendothelin, and that human endothelin is identical with porcine endothelin.