Organic Letters 2005-09-29

Palladium-catalyzed carbonylation of yne esters leading to gamma-alkylidene alpha,beta-unsaturated gamma-lactones.

Yasuyuki Harada, Yoshiya Fukumoto, Naoto Chatani

Index: Org. Lett. 7 , 4385, (2005)

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Abstract

[reaction: see text] The reaction of yne esters with carbon monoxide (1 atm) in the presence of palladium complexes gives bicyclic unsaturated lactone derivatives in good to high yields. The 2-pyridinyloxy group is a good leaving group among leaving groups examined.