Pharmaceuticals 2013-01-01

The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists.

Huayun Deng, Ye Fang

Index: Pharmaceuticals (Basel.) 6 , 500-9, (2013)

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Abstract

Nearly 1% of all clinically used drugs are catecholics, a family of catechol-containing compounds. Using label-free dynamic mass redistribution and Tango β-arrestin translocation assays, we show that several catecholics, including benserazide, catechol, 3-methoxycatechol, pyrogallol, (+)-taxifolin and fenoldopam, display agonistic activity against GPR35.