China Journal of Chinese Materia Medica 2009-06-01

[Studies on antibacterial constituents of Discocleidion rufescens (2)].

Ye Tian, Haifeng Tang, Xiaojuan Wang, Feng Qiu, Gaijin Xue, Jun Li

Index: Zhongguo Zhong Yao Za Zhi 34 , 1377-1380, (2009)

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Abstract

To screen effective constituents of Discocleidion rufescens against bacteria.Compounds were isolated by bioassay-guided fractionation method with various chromatographic methods and their structures were determined by spectral analysis and chemical evidence.Seven compounds were isolated from the Et2O and n-BuOH extracts and identified as 5,7-dihydroxy-4'-methoxy flavone (1), quercetin (2), apigenin-7-O-beta-D-glucopyranoside (3), apigenin-7-O-neohesperidoside (4), luteolin-7-O-neohesperidoside (5), gallic acid (6) and beta-daucosteol (7).Compounds 1-6 were isolated from genus Discocleidion for the first time and exhibited certain inhibitory activity against Escherichia coli. Compound 6 also showed antibacterial activity against Staphylococus aureus.