Journal of Antibiotics 1997-12-01

Roseocardin, a novel cardiotonic cyclodepsipeptide from Trichothecium roseum TT103.

A Tsunoo, M Kamijo, N Taketomo, Y Sato, K Ajisaka

Index: J. Antibiot. 50(12) , 1007-13, (1997)

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Abstract

A new cyclodepsipeptide, designated roseocardin, was isolated from the culture broth of Trichothecium roseum TT103. Roseotoxin B and destruxins A and B were also isolated during the same procedure. The structure of roseocardin was determined by EI-MS, NMR and X-ray crystallographic analysis. Roseocardin as well as the other cyclodepsipeptides were shown to produce positive inotropic effects on rat heart muscles.