Tetrahedron Letters 2012-04-01

Diversity Oriented Synthesis: Concise Entry to Novel Derivatives of Yohimbine and Corynanthe Alkaloids.

Zhiqian Wang, Kyosuke Kaneda, Zhenglai Fang, StephenF Martin

Index: Tetrahedron Lett. 53(5) , 477-479, (2012)

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Abstract

A novel MCAP-cycloaddition sequence has been applied to the facile synthesis of _-carboline intermediates to gain rapid access to novel derivatives of yohimbine-like and corynanthe-like compounds that may be easily diversified by cross-coupling reactions and N-derivatizations to generate small compound libraries.