Chemical Communications 2011-05-14

Rational design of a Tn antigen mimic.

Francisco Corzana, Jesús H Busto, Filipa Marcelo, Marisa García de Luis, Juan L Asensio, Sonsoles Martín-Santamaría, Yolanda Sáenz, Carmen Torres, Jesús Jiménez-Barbero, Alberto Avenoza, Jesús M Peregrina

Index: Chem. Commun. (Camb.) 47(18) , 5319-21, (2011)

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Abstract

A novel Tn antigen mimic, in which the natural underlying amino acid has been replaced by the non-natural α-methylserine analogue, is reported. This derivative exhibits a similar affinity for a natural lectin as for the natural Tn and retains the bioactive conformation observed in the Tn-containing glycopeptides with anti-MUC1 antibodies.© The Royal Society of Chemistry 2011