Acta Crystallographica Section F 2008-07-01

Complexes of the copper-containing amine oxidase from Arthrobacter globiformis with the inhibitors benzylhydrazine and tranylcypromine.

David B Langley, Daniel M Trambaiolo, Anthony P Duff, David M Dooley, Hans C Freeman, J Mitchell Guss

Index: Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64(Pt 7) , 577-83, (2008)

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Abstract

Complexes of Arthrobacter globiformis amine oxidase (AGAO) with the inhibitors benzylhydrazine and tranylcypromine (an antidepressant drug) have been refined at 1.86 and 1.65 A resolution, respectively. Both inhibitors form covalent adducts with the TPQ cofactor. A tyrosine residue, proposed to act as a gate to the AGAO active site, is in its open conformation.