Ketoester methacrylate resin, secondary amine clean-up in the presence of primary amines

Z Yu, S Alesso, D Pears, PA Worthington…

Index: Yu; Alesso; Pears; Worthington; Luke; Bradley Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 16 p. 1947 - 1952

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Abstract

A ketoester resin was developed as the basis for a selective scavenger for primary amines in the presence of secondary amines. The utility of the scavenger was demonstrated with a range of reductive amination chemistries with both mono-and diamines. The resin's specificity is based on the removal of the primary amines via their enamines.