Synthesis and anticonvulsant activity of some N-(benzoyl) glycinanilide derivatives

Z Soyer, O Akgul, AH Tarikogullari, U Calis

Index: Soyer, Zeynep; Akgul, Ozlem; Tarikogullari, Ayse H.; Calis, Unsal Medicinal Chemistry Research, 2013 , vol. 22, # 10 p. 4708 - 4714

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Abstract

Abstract Glycine is a major inhibitory neurotransmitter and recent studies have shown that certain lipophilic glycine derivatives demonstrate anticonvulsant activity in animal epilepsy models. On the other hand, anilide is another fruitful structure for designing potential anticonvulsant agents. Ameltolide, ralitoline and some phthalimide derivatives are the examples of anilide analogs with potent anticonvulsant activity. In this study, two key ...