Relationship of structure to acute toxicity and antiarrhythmic activity in alkylamino-and dialkylaminoacet-ortho-toluidides

…, VI Pantsurkin, VN Ryazanov, VV Gorbunova…

Index: Shklyaev, V.S.; Pantsurkin, V.I.; Ryazanov, V.N.; Gorbunova, V.V.; Sukhanov, A.A.; et al. Pharmaceutical Chemistry Journal, 1992 , vol. 26, # 4 p. 338 - 343 Khimiko-Farmatsevticheskii Zhurnal, 1992 , vol. 26, # 4 p. 51 - 55

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Abstract

The IR spectra of O. Ol M solutions of the bases (I-XXIII) in chloroform showed the presence of intramolcule hydrogen bonding (IBH) between the hydrogen on the amide nitrogen and the amino-group [5]. The strength of the IHB is shown by the considerable shift in the absorption for stretching vibrations of the NH group (AVNH), amounting for example to 175 cm-~ in (VIII). The substituents at the amine nitrogen, by virtue of their negative inductive ...