Activity of the C-terminal part of substance P on guinea pig ileum and trachea preparations I. N-acylated pentapeptides SP (7–11)

…, S Magneney, PP Van Chuong, P Schmitt…

Index: Michelot; Mayer; Magneney; Pham Van Chuong; Schmitt; Potier European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 243 - 247

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Citation Number: 9

Abstract

Abstract Acylated pentapeptide X Phe Phe Gly Leu MetNH 2 analogs of the substance P (7–11) sequence were synthesized by solution method and their spasmogenic activities were evaluated on guinea pig ileum (GPI) and trachea (GPT). Pentapeptide SP (7– 11) had the lowest potency and its N-acylation increased its activity in both tests, with some derivatives being more active than SP itself. Results obtained on GPI suggest a close ...