Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues

MK Prashanth, HD Revanasiddappa, KML Rai…

Index: Prashanth; Revanasiddappa, Hosakere D.; Lokanatha Rai; Veeresh Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 23 p. 7065 - 7070

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Citation Number: 21

Abstract

A series of piperamide derivatives (8a–j) was synthesized with various substituted piperidine and piperazine compounds. The prepared compounds were evaluated for antibacterial activity against gram-positive and gram-negative bacteria and antifungal activity by disc diffusion method. The antioxidant activity of the compounds was evaluated by DPPH and superoxide radical scavenging method and antidepressant activity using forced swim and ...