Tetrahedron

Mechanistic studies in the radical induced DNA strand cleavage—Formation and reactivity of the radical cation intermediate

R Glatthar, M Spichty, A Gugger, R Batra, W Damm…

Index: Glatthar, Ralf; Spichty, Martin; Gugger, Andreas; Batra, Rohit; Damm, Wolfgang; Mohr, Matthias; Zipse, Hendrik; Giese, Bernd Tetrahedron, 2000 , vol. 56, # 25 p. 4117 - 4128

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Citation Number: 30

Abstract

In order to understand the heterolytic cleavage of 4′-DNA radical 1 and the regioselective attack of nucleophiles at the intermediate DNA radical cation 3, the chemistry of model radical 8 was studied. It turned out that the heterolytic cleavage in water is favored over ...