Chemical & Pharmaceutical Bulletin 2012-01-01

Molecular symmetry and biological activities of new symmetrical tris(2-aminoethyl)amine derivatives.

Nobuko Mibu, Kazumi Yokomizo, Wataru Uchida, Satoshi Takemura, Jianrong Zhou, Hatsumi Aki, Takeshi Miyata, Kunihiro Sumoto

Index: Chem. Pharm. Bull. 60(3) , 408-14, (2012)

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Abstract

In terms of molecular symmetry and bioactivity, new C3- and CS-symmetrical derivatives based on the tris(2-aminoethyl)amine scaffold were designed and synthesized. The synthesized compounds were evaluated for antiviral activity with herpes simplex virus type 1 (HSV-1) by a plaque reduction assay and for cytotoxic activity with Vero cells. Most of the compounds showed no significant anti-HSV-1 activity, but some of the symmetrical derivatives showed high levels of cytotoxic activitiy.