Novel synthesis of [13C4, 15N] 1H??pyrrole??2, 3, 5??tricarboxylic acid: an important biomarker for melatonin metabolism

MB Skaddan

Index: Skaddan, Marc B. Journal of Labelled Compounds and Radiopharmaceuticals, 2010 , vol. 53, # 2 p. 73 - 77

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Citation Number: 2

Abstract

Abstract 1H-pyrrole-2, 3, 5-tricarboxylic acid is a breakdown product of melatonin. A labeled version of this compound would serve as a key biomarker for drug candidates which track this substance to monitor their effectiveness (eg hyperpigmentation drugs). A Hantzsch synthesis using readily available starting materials was used to generate [13 C 4, 15 N] 1H- pyrrole-2, 3, 5-tricarboxylic acid in six steps (12% overall yield). Copyright© 2009 John ...