Applied Radiation and Isotopes 2011-12-01

Boron neutron capture therapy for clear cell sarcoma (CCS): biodistribution study of p-borono-L-phenylalanine in CCS-bearing animal models.

T Andoh, T Fujimoto, T Sudo, I Fujita, M Imabori, H Moritake, T Sugimoto, Y Sakuma, T Takeuchi, S Kawabata, M Kirihata, T Akisue, K Yayama, M Kurosaka, S Miyatake, Y Fukumori, H Ichikawa

Index: Appl. Radiat. Isot. 69(12) , 1721-4, (2011)

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Abstract

Clear cell sarcoma (CCS) is a rare melanocytic malignant tumor with a poor prognosis. Our previous study demonstrated that in vitro cultured CCS cells have the ability to highly uptake l-BPA and thus boron neutron capture therapy could be a new option for CCS treatment. This paper proved that a remarkably high accumulation of (10)B (45-74 ppm) in tumor was obtained even in a CCS-bearing animal with a well-controlled biodistribution followed by intravenous administration of L-BPA-fructose complex (500 mg BPA/kg).Copyright © 2011 Elsevier Ltd. All rights reserved.