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e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Condensation of Thiophenols and Formaldehyde with Some Aromatic Amines

GF GRILLOT, RE SCHAFFRATH

Index: Grillot; Schaffrath Journal of Organic Chemistry, 1959 , vol. 24, p. 1035,1036

Full Text: HTML

Citation Number: 24

Abstract

Two arylaminoethyl aryl sulfides were prepared by condensing P-chloroethylaniline with the sodium salt of the thiophenol. Basicities of these arylaminoalkyl aryl sulfides have been related to (a) the presence of electrophilic substituents attached to the aryl groups and (b)

 Related Synthetic Route
Formaldehyde Structure

50-00-0

Formaldehyde

p-Toluidine Structure

106-49-0

p-Toluidine

4-Chlorothiophenol Structure

106-54-7

4-Chlorothiophenol

~%

(3Z)-3-[(4-nitrophenyl)methylidene]-8-phenyl-4-thia-1,6,7-triazabicyclo[3.3.0]octa-5,7-dien-2-one Structure

6632-00-4

(3Z)-3-[(4-nitr...

Formaldehyde Structure

50-00-0

Formaldehyde

4-Chlorothiophenol Structure

106-54-7

4-Chlorothiophenol

N-Methyl-4-anisidine Structure

5961-59-1

N-Methyl-4-anisidine

~%

Benzenamine,N-[[(4-chlorophenyl)thio]methyl]-4-methoxy-N-methyl- Structure

6632-06-0

Benzenamine,N-[...

Formaldehyde Structure

50-00-0

Formaldehyde

2,4,6-trimethylthiophenol Structure

1541-10-2

2,4,6-trimethyl...

2,4,6-Trimethylaniline Structure

88-05-1

2,4,6-Trimethyl...

~%

Benzenamine,2,4,6-trimethyl-N-[[(2,4,6-trimethylphenyl)thio]methyl]- Structure

6629-72-7

Benzenamine,2,4...

Formaldehyde Structure

50-00-0

Formaldehyde

3-Chloroaniline Structure

108-42-9

3-Chloroaniline

4-Chlorothiophenol Structure

106-54-7

4-Chlorothiophenol

~%

Benzenamine,3-chloro-N-[[(4-chlorophenyl)thio]methyl]- Structure

956-65-0

Benzenamine,3-c...

Formaldehyde Structure

50-00-0

Formaldehyde

p-Toluidine Structure

106-49-0

p-Toluidine

4-Chlorothiophenol Structure

106-54-7

4-Chlorothiophenol

~%

Benzenamine,N,N-bis[[(4-chlorophenyl)thio]methyl]-4-methyl- Structure

6969-13-7

Benzenamine,N,N...

Formaldehyde Structure

50-00-0

Formaldehyde

4-Nitroaniline Structure

100-01-6

4-Nitroaniline

4-Chlorothiophenol Structure

106-54-7

4-Chlorothiophenol

~%

Benzenamine, N-[[ (4-chlorophenyl)thio]methyl]-4-nitro- Structure

6631-87-4

Benzenamine, N-...

Formaldehyde Structure

50-00-0

Formaldehyde

4-Chlorothiophenol Structure

106-54-7

4-Chlorothiophenol

N-Methyl-4-nitroaniline Structure

100-15-2

N-Methyl-4-nitr...

~%

N-[(4-chlorophenyl)sulfanylmethyl]-N-methyl-4-nitro-aniline Structure

6631-98-7

N-[(4-chlorophe...

Formaldehyde Structure

50-00-0

Formaldehyde

Thiophenol Structure

108-98-5

Thiophenol

N-Methylaniline Structure

100-61-8

N-Methylaniline

~%

Benzenamine, N-methyl-N-[(phenylthio)methyl]- Structure

13641-16-2

Benzenamine, N-...

Formaldehyde Structure

50-00-0

Formaldehyde

p-Anisidine Structure

104-94-9

p-Anisidine

4-Chlorothiophenol Structure

106-54-7

4-Chlorothiophenol

~%

Benzenamine, N-[[(4-chlorophenyl)thio]methyl]-4-methoxy- Structure

6631-99-8

Benzenamine, N-...

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Detail Synthetic Route


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