Bioorganic & Medicinal Chemistry Letters 1999-07-19

Synthesis of probes for the active site of leucine dehydrogenase.

A Sutherland, C L Willis

Index: Bioorg. Med. Chem. Lett. 9(14) , 1941-4, (1999)

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Abstract

A series of novel 3-substituted 2-oxobutanoic acids were prepared and incubated with leucine dehydrogenase giving in one case both a kinetic resolution at C-3 and reductive amination of the ketone. This is the first example of an amino acid dehydrogenase catalysed kinetic resolution and reductive amination.