Organic Letters 2005-12-08

Formal syntheses of (+/-)-pinnaic acid and (+/-)-halichlorine.

Rodrigo B Andrade, Stephen F Martin

Index: Org. Lett. 7(25) , 5733-5, (2005)

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Abstract

[chemical reaction: see text]. Concise formal syntheses of marine alkaloids (+/-)-pinnaic acid (1) and (+/-)-halichlorine (2) have been accomplished from a common intermediate. The syntheses illustrate the utility of selective olefin cross metathesis methodologies for the elaboration of advanced synthetic intermediates in complex molecule synthesis.