Annales of National Institute of Hygiene/Roczniki Panstwowego Zakladu Higieny 1992-01-01

[Changes in activity of G-6-pase, APase, and gamma-GTPase in liver and blood serum of rats exposed to nuarimol and NDEA].

B Wiadrowska, J K Ludwicki, D Palut

Index: Rocz. Panstw. Zakl. Hig. 43(3-4) , 281-7, (1992)

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Abstract

The effect of simultaneous administration of N-diethylnitrosamine (NDEA) and Nuarimol on the activity of gamma-GTPase, G-6-Pase ans APase in the liver and serum of Wistar rats was investigated in the 2-weeks experiment. The two-stage hepato-cancerogenesis model was used with NDEA as initiating agent. The possible promoting potential of Nuarimol (DDT analogue) was checked in this experiment. gamma-GTPase and G-6-Pase activities were measured by biochemical and histochemical methods and AP-ase activity was measured by a biochemical method only. The occurrence of gamma-GTPase positive foci found by histochemical methods was partly confirmed by colorimetric methods. This suggest the need for further examination of this enzyme in conditions of prolonged exposure to Nuarimol.