Brain Research Bulletin 2011-01-01

Different effects of α-chloralose on spontaneous and evoked GABA release in rat hippocampal CA1 neurons

Tatsuya Matsuura, Satomi Iwata, Min-Chul Shin, Masahito Wakita, Sachie K. Ogawa, Norio Akaike, Tatsuya Matsuura, Satomi Iwata, Min-Chul Shin, Masahito Wakita, Sachie K. Ogawa, Norio Akaike

Index: Brain Res. Bull. 85(3-4) , 180-8, (2011)

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Abstract

Highlights ► Modulation of α-chloralose on extra- and intra-synaptic GABA A receptors. ► α-Chloralose dose dependently potentiates exogenous GABA-induced Cl − response. ► 10 μM α-Chloralose facilitates sIPSC frequency, and decreased failure rate of eIPSC. ► 30 μM α-Chloralose induces presynaptic inhibition of eIPSC.