Biochimica et Biophysica Acta 1984-12-07

Silicon compounds as substrates and inhibitors of acetylcholinesterase.

A Aberman, D Segal, Y Shalitin, A L Gutman

Index: Biochim. Biophys. Acta 791(2) , 278-80, (1984)

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Abstract

Several trimethylsilyl derivatives were found to be ligands of acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7): trimethylsilylethyl acetate (III) and trimethylsilylmethyl acetate (V) are substrates of the enzyme, whereas trimethylsilylethanol (VIII) is a competitive inhibitor. The silicon compounds have kinetic parameters similar to those of their carbon analogues, except for trimethylsilylmethyl acetate, which is a substrate of acetylcholinesterase, whereas its carbon analogue is not susceptible to enzymic hydrolysis.