Fundamental and Applied Toxicology 1986-08-01

A subchronic, teratologic, and dominant lethal study of 2-methylresorcinol in rats. II. Teratologic and dominant lethal study.

T A Re, R F Loehr, S C Rodriguez, D E Rodwell, C M Burnett

Index: Fundam. Appl. Toxicol. 7(2) , 293-8, (1986)

Full Text: HTML

Abstract

2-Methylresorcinol (2-MR) was administered to groups of 40 male and 35 female Sprague-Dawley rats by admixture with the diets at levels of 0.1, 0.4, and 1.5% (see Part I; T.H. Re, R.F. Loehr, S.C. Rodriguez, C.E. Gilmore, and C.M. Burnett, 1986, Fundam. Appl. Toxicol. 7, 287-292). Following 90 days of exposure, 25 randomly selected females in each group were mated to untreated males in a teratology study in which exposure to 2-MR continued throughout the gestation period. After 20 weeks of exposure to 2-MR, 20 males per group were removed from the test diets containing 2-MR and were mated to untreated females in a dominant lethal study. Feeding 2-MR at levels of 0.4 and 1.5% in the diet was associated with a significant reduction in body weight gain. 2-MR was not teratogenic nor did it induce a dominant lethal effect under the conditions of this study.