Polish journal of pharmacology and pharmacy 1987-01-01

The effect of methylbromophenvinfos (Polfos) on some enzymes in vivo and in vitro. I. In vivo studies.

D Pawłowska, D Koćmierska-Grodzka, J Moniuszko-Jakoniuk

Index: Pol. J. Pharmacol. Pharm. 39(4) , 361-70, (1987)

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Abstract

The experiment was carried out on Wistar rats receiving orally either oil or oily solution of methylbromophenvinfos (Polfos) either in a single dose of 0.5 LD50, or doses of 0.1 LD50 once daily for a period of 2, 4 or 6 weeks. The activities of cholinesterase (ChE), beta-glucuronidase (beta-glu), lipase and amylase were assayed in the blood serum, the activity of acetylcholinesterase (AChE)-in brain homogenates, and the activities of lipase and amylase-in homogenates of the pancreas. Cholinesterases were inhibited in the course of both acute and chronic poisoning with Polfos. During the acute poisoning a sharp increase in the activity of beta-glu in the blood serum, 1 and 2 h after the pesticide administration, was observed. Polfos inhibited lipase and amylase both after acute and chronic treatment.