Biochimica et Biophysica Acta 1989-05-31

Monooxygenation of N-acetylhistamine mediated by L-ascorbate.

K Uchida, M Mitsui, S Kawakishi

Index: Biochim. Biophys. Acta 991(2) , 377-9, (1989)

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Abstract

In the presence of molecular oxygen and a catalytic amount of copper(II) ion, ascorbate almost completely degraded histamine (approx. 72%). The reaction was shown to occur at the imidazole group but not at the primary amino group in histamine. 4-[2-(Acetylamino)ethyl]-2,3-dihydroimidazol-2-one, a monooxygenated form of N-acetylhistamine, was first isolated as the primary product.