Biochemical and Biophysical Research Communications 2011-01-01

γ-Tubulin localizes at actin-based membrane protrusions and inhibits formation of stress-fibers

Thomas Hubert, Sofie Perdu, Joël Vandekerckhove, Jan Gettemans, Thomas Hubert, Sofie Perdu, Joël Vandekerckhove, Jan Gettemans

Index: Biochem. Biophys. Res. Commun. 408 , 248-52, (2011)

Full Text: HTML

Abstract

Highlights ► γ-Tubulin localizes at actin-based membrane protrusions. ► The localization was supported by knock-down and overexpression of γ-tubulin. ► Expression of tagged γ-tubulin dramatically inhibited the formation of stress-fibers. ► This phenotype is similar to that obtained by overexpression of WCA domains.