Anticancer Research 1993-01-01

Antiplasmid and carcinogenic molecular orbitals of benz[c]acridine and related compounds.

J Molnar, S Petofi, T Kurihara, H Sakagami, N Motohashi

Index: Anticancer Res. 13(1) , 263-6, (1993)

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Abstract

Effect of K- and L- molecular orbital regions on expression of antiplasmid and carcinogenic activity was studied with various benz[c]acridine derivatives, tricyclic compounds (acridine orange, phenothiazines) and dibenzoazepine (imipramine). Antiplasmid compounds showed the out-of-phase of molecular orbital in the L-region. On the other hand, mutagenic and carcinogenic compounds showed the out-of-phase in the L-region, and their energy was accumulated in the K-region of the molecular orbitals. The present study suggests that the molecular orbitals responsible for the expression of antiplasmid and carcinogenic effects might be basically different.