BENZ(C)ACRIDINE

Modify Date: 2024-01-08 19:04:48

BENZ(C)ACRIDINE Structure
BENZ(C)ACRIDINE structure
Common Name BENZ(C)ACRIDINE
CAS Number 225-51-4 Molecular Weight 229.276
Density 1.2±0.1 g/cm3 Boiling Point 446.2±14.0 °C at 760 mmHg
Molecular Formula C17H11N Melting Point 132°C
MSDS N/A Flash Point 201.4±12.7 °C

 Names

Name benzo[c]acridine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 446.2±14.0 °C at 760 mmHg
Melting Point 132°C
Molecular Formula C17H11N
Molecular Weight 229.276
Flash Point 201.4±12.7 °C
Exact Mass 229.089142
PSA 12.89000
LogP 4.63
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.783

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CU2975000
CHEMICAL NAME :
Benz(c)acridine
CAS REGISTRY NUMBER :
225-51-4
BEILSTEIN REFERENCE NO. :
0154999
LAST UPDATED :
199612
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C17-H11-N
MOLECULAR WEIGHT :
229.29
WISWESSER LINE NOTATION :
T D6 B666 CNJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2400 mg/kg/67W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9630 mg/kg/3D-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 118,103,1983 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 32,129,1983 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 32,129,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987

 Safety Information

RIDADR UN 2811
Packaging Group III
Hazard Class 6.1(b)
HS Code 2933990090

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles25

More Articles
Substituted benz[a]acridines and benz[c]acridines as mammalian topoisomerase poisons.

Bioorg. Med. Chem. 8(5) , 1171-82, (2000)

Coralyne and several other synthetic benzo[a,g]quinolizium derivatives related to protoberberine alkaloids have exhibited activity as topoisomerase poisons. These compounds are characterized by the pr...

Heteroatom effects in chemical carcinogenesis: effects of ring heteroatoms on ease of carbocation formation.

Cancer Biochem. Biophys. 7(1) , 53-60, (1983)

The presence of a heteroatom can influence the ease with which a PAH diol-epoxide forms a triol carbocation. The influence of the heteroatom should be greatest when it is located where the PAH undergo...

Differentiated genotoxic response of carcinogenic and non-carcinogenic benzacridines and metabolites in rat hepatoma cells.

Carcinogenesis 6(3) , 455-7, (1985)

Two closely related hepatoma cell lines were examined for their genotoxic response to benacridines and their metabolites by the appearance of alkaline labile DNA sites: H5, a dedifferentiated line exp...

 Synonyms

3,4-Benzacridine
Benzo[c]acridine
3,4-Benzoacridine
BENZ(C)ACRIDINE
12-Azabenz[a]anthracene
Benz[c]acridine
7,8-Benzacridine