Annales d'Endocrinologie 1999-07-01

Mechanism of GnRH receptor signaling: from the membrane to the nucleus.

S Shacham, M N Cheifetz, H Lewy, I E Ashkenazi, O M Becker, R Seger, Z Naor

Index: Ann. Endocrinol. 60 , 79-88, (1999)

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Abstract

The purpose of this review is to update the information concerning the intracellular effect of GnRH. Binding of GnRH to a G-protein coupled receptor leads to stimulation of Gq and/or G11 protein and to activation of phospholipase C beta. Inositol 1-4-5-triphosphate and early diacylylycerol are the second messengers required for conventional protein kinase C activation. Activation of phospholipase A2 and phospholipase D are also involved, as demonstrated by the liberation of Arachidonic Acid and Phosphatidic Acid. Pituitary cells also express atypical protein kinase C isoforms which mode of activation is not known. Hypothesis concerning transcriptional regulation are presented.