Bioorganic & Medicinal Chemistry Letters 2002-12-02

Structure-activity relationships for a series of thiobenzamide influenza fusion inhibitors derived from 1,3,3-trimethyl-5-hydroxy-cyclohexylmethylamine.

Kuo Long Yu, Albert F Torri, Guangxiang Luo, Christopher Cianci, Katharine Grant-Young, Stephanie Danetz, Lawrence Tiley, Mark Krystal, Nicholas A Meanwell

Index: Bioorg. Med. Chem. Lett. 12(23) , 3379-82, (2002)

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Abstract

The anti-influenza activity of a series of thiobenzamide fusion inhibitors derived from 1,3,3-trimethyl-5-hydroxy-cyclohexylmethylamine is profiled. Axial disposition of the thioamide moiety is essential for potent influenza inhibitory activity.