Biochemistry international 1991-05-01

Amphotericin B stimulates secretion of beta-hexosaminidase from mouse adherent spleen cells.

T Beccari, R Mazzolla, E Constanzi, A Datti, R Barluzzi, F Bistoni, A Orlacchio

Index: Biochem. Int. 24(2) , 235-41, (1991)

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Abstract

Secretion of the lysosomal enzyme hexosaminidase is induced by amphotericin B in mouse spleen adherent cells that show a significant increase in their candidacidal activity. The stimulation of beta-hexosaminidase is both time and dose dependent. Amphotericin B treatment did not change hexosaminidase expression that is represented mainly by "A-type" hexosaminidase in macrophages, on the basis of its biochemical properties.