Chemistry Letters

Facile synthesis of dialkyl fluoromalonates and their derivatives.

N Ishikawa, A Takaoka

Index: Ishikawa, Nobuo; Takaoka, Akio Chemistry Letters, 1981 , p. 107 - 110

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Citation Number: 9

Abstract

Dimethyl and diethyl fluoromalonates were prepared by the stepwise basic alcoholysis of hexafluoropropene in a total yield of 50–55%. These dialkyl fluoromalonates were alkylated with alkyl halides, and the resulting dialkyl α-fluoroalkylmalonates were cyclized with urea affording 5-fluorobarbituric acid derivatives.