Bioorganic & Medicinal Chemistry Letters 2001-01-22

Arylalkylidene rhodanine with bulky and hydrophobic functional group as selective HCV NS3 protease inhibitor.

W T Sing, C L Lee, S L Yeo, S P Lim, M M Sim

Index: Bioorg. Med. Chem. Lett. 11(2) , 91-4, (2001)

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Abstract

Arylalkylidene rhodanines 2(a-d) inhibit HCV NS3 protease at moderate concentrations. They are better inhibitors of other serine proteases such as chymotrypsin and plasmin. However, the selectivity of arylmethyliden e rhodanines (8a, 9a) with bulkier and more hydrophobic functional groups increases by 13- and 25-fold towards HCV NS3 protease respectively.